The movie crossed 100 crores after it's second weekend (10 days) making it the 2nd fastest 100 crore grosser at the time after Enthiran beating Thuppakki's record. The movie finished most of it's business in India excluding Tamil Nadu by then. Despite having a short run, the movie became profitable in it's Hindi version. The movie had a short run in it's Telugu version too but couldn't became profitable. An interesting factor in Vishwaroopam's performance was that the number of shows dropped by 55% from week 1 to week 2. This is because of the number of movies that released along side Vishwaroopam. If it wasn't for those movies, Vishwaroopam would have kept 200 of it's shows in the 2nd week and would have held a bigger collection in Tamil Nadu. But even with all that, the movie kept a strong performance. The delay factored into it's collections too. The movie had a chance of collecting an extra 12 crores or more if it's wasn't for the delay. Malaysia, the biggest market for Tamil films outside of India, witnessed a delay along with protests. This later on resulted the movie to gross a disappointing 2 crores there. The movie had a good chance to cross 10 crores in Malaysia if it wasn't the controversy. The movie ended up crossing 107 crores at the worldwide box office. Despite having a good performance and putting up good figures, the movie suffered a 8.75 crore loss with 8 crores from Tamil Nadu. Overall the movie was an average earner for distributors.

The movie released in 2290 screens worldwide. Around 450 screens were from Tamil Nadu itself. Chennai contributed 49 screens. Another 300 screens were added from Andhra Pradesh/Telengana. The movie got 90 screens from Kerala and another 50 from Karnataka. Vishwaroopam's Hindi version “Vishwaroop” released in over 1000 screens in India. Kamal's movie didn't get many screens in big markets like Malaysia, Sri Lanka, and the Gulf due to it's protests on the ban of it's release. Vishwaroopam was released on about 250 screens overseas and 2040 screens in India. With this Vishwaroopam was the second biggest release ever in Tamil cinema after Enthiran.