Vedalam was a blockbuster for Ajith and director Siva. The movie did great business for an Ajith film and was the actor's first film to do 100 crores worldwide. It finished with a gross of 116 crores with 84.8 crores from India and USD$4.69M abroad.

Vedalam brought Ajith's market to a better level in Tamil Nadu. The film attracted family audiences and did great business outside A centers. Ajith was always at a disadvantage for not having a loyal family audience base and B & C center audience but Vedalam changed that for the hero. Vedalam grossed a huge 70.90 crores in Tamil Nadu becoming the 4th highest grossing film in the state after Enthiran, "I", and Thuppakki.

Siva's directional gave profits in most areas. The movie was in red in Karnataka but gave out profits in all other Indian territories. Vedalam did great business abroad especially in Malaysia and Sri Lanka. Europe and Singapore on the other hand were relatively poor to other territories.

Despite mixed reviews from critics, Vedalam proved to be a huge success at the box office. The movie is declared a "Blockbuster".

Vedalam opened to huge numbers worldwide becoming Ajith’s biggest opener. It held the biggest opening in Tamil Nadu ever crossing the previous record set by Shankar’s “I”. The film held records for an Ajith starer in Kerala, Karnataka, and the rest of India. Overseas the film grossed a huge 23.75 crores in the weekend. The film set the record for the biggest Indian weekend in Malaysia grossing a massive 10 crores. The film had a great opening in the UAE and Sri Lanka as well. The film grossed a total of about 80 crores worldwide after it’s 6-day weekend, the highest non-Rajini/Shankar opening.